About Us

Meet the Consultants

Seek important information or advice from our expert and professional consultants.

Dr Andreas Kyriacou

Consultant Cardiologist and Electrophysiologist
www.bmihealthcare.co.uk/consultants/andreas-kyriacou

Dr Nick Kelland

Consultant Cardiologist and Electrophysiologist
www.bmihealthcare.co.uk/consultants/nicholas-kelland

Dr Andreas Kyriacou

Specialties

Consultant Cardiologist and Electrophysiologist
Honorary Senior Clinical Lecturer, Sheffield University

Specialist Clinical Interests

Medical treatment and ablation of heart rhythm disorders including complex arrhythmias such as atrial fibrillation and ventricular tachycardia.
Implantation of complex cardiac pacemakers and defibrillators.

Research Interests

Investigating the effects of complex cardiac pacing on heart function and coronary artery physiology.
Maximizing the benefits derived from cardiac pacemakers and cardiac resynchronisation therapy.

Developing new diagnostic and treatment approaches in complex arrhythmias.

Professional Profile

Dr Andreas Kyriacou graduated from the University of Edinburgh in 2001 and in the following years he acquired clinical experience as a junior doctor in Edinburgh and London. In 2007, he was awarded the Walport Academic Clinical Fellowship in Cardiology by the NIHR and subsequently trained in Cardiology and subspecialised in Cardiac arrhythmias in prominent Heart centres in London.

He worked at St Marys and Hammersmith Hospitals of Imperial College Healthcare NHS Trust, where he also carried out research (awarded a 3-year clinical research training fellowship by the BHF) in complex cardiac pacemakers at the International Centre for Circulatory Health. He explored the physiological effects of complex pacing on heart function and developed treatments to improve patient outcomes. This work led to a number of high impact publications and was recognised by the European Society of Cardiology Heart Failure Association (Winner of the Young Investigator in Clinical Research, 2012) and the British Heart Rhythm Society (Runner up in the Young Investigator Competition, 2012). His research findings were presented in 2011 and 2012 at the ‘SET for Britain’ ceremonies, hosted by the Parliamentary and Scientific Committee at Westminster.

He concluded his training in cardiac arrhythmias at the Royal Brompton and Harefield Hospitals where he focused on the ablation of complex arrhythmias including atrial fibrillation and ventricular tachycardias in a variety of complex patient groups.

In 2015, he was appointed to the post of Consultant Cardiologist and Electrophysiologist at Sheffield Teaching Hospitals NHS Foundation Trust.

Education and Training

  • 2013 – International Board of Heart Rhythm Examiners (IBHRE), Certified Cardiac  Device Specialist (CCDS)
  • 2009 – 2012 Clinical Research Training Fellowship, British Heart Foundation.
  • 2008 – 2011 Doctor of Philosophy, National Heart and Lung Institute, Imperial College London, UK
  • 2007 – 2015 Academic Clinical National Training Number in Cardiology (Walport NIHR Fellowship), NW Thames, London.
  • 2004 – MRCP, Royal College of Physicians, London
  • 1996 – 2001 MBChB, Faculty of Medicine, University of Edinburgh

Current membership(s) of professional, national and regional bodies and university posts

  • Honorary Senior Lectureship, Sheffield University
  • Member Royal College of Physicians of EdinburghMember of British
  • Heart Rhythm Society
  • Member of Hospital Consultants and Specialists Association

Publications

Original Papers

  1. Kyriacou A, Rajkumar CA, Pabari PA, Sohaib SA, Willson K, Peters NS, Lim PB, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP. Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT. Pacing Clin Electrophysiol. 2018 Jun 1. doi:10.1111/pace.13401. [Epub ahead of print] PubMed PMID: 29856077.
  2. Whinnett ZI, Sohaib SMA, Mason M, Duncan E, Tanner M, Lefroy D, Al-Obaidi M, Ellery S, Leyva-Leon F, Betts T, Dayer M, Foley P, Swinburn J, Thomas M, Khiani R, Wong T, Yousef Z, Rogers D, Kalra PR, Dhileepan V, March K, Howard J, Kyriacou A, Mayet J, Kanagaratnam P, Frenneaux M, Hughes AD, Francis DP. Multicenter Randomized Controlled Crossover Trial Comparing Hemodynamic Optimization Against Echocardiographic Optimization of AV and VV Delay of Cardiac Resynchronization Therapy: The BRAVO Trial. JACC Cardiovasc Imaging. 2018 May 11. pii: S1936-878X(18)30211-0. doi: 10.1016/j.jcmg.2018.02.014. [Epub ahead of print] PubMed PMID: 29778861.
  3. Kyriacou A, Hayat S, Qureshi N, Peters NS, Kanagaratnam P, Lim PB. Dissociated pulmonary vein potentials: Expression of the cardiac autonomic nervous system following pulmonary vein isolation? Heart Rhythm Case Rep. 2015 Sep 4;1(6):401-405
  4. Sohaib SM, Kyriacou A, Jones S, Manisty CH, Mayet J, Kanagaratnam P, Peters NS, Hughes AD, Whinnett ZI, Francis DP. Evidence that conflict regarding size of haemodynamic response to interventricular delay optimization of cardiac resynchronization therapy may arise from differences in how atrioventricular delay is kept constant. Europace. 2015 Dec;17(12):1823-33
  5. Finegold J, Bordachar P, Kyriacou A, Sohaib SM, Kanagaratnam P, Ploux S, Lim B, Peters N, Davies W, Ritter P, Francis DP, Whinnett ZI. Atrioventricular delay optimization of cardiac resynchronisation therapy: Comparison of non-invasive blood pressure with invasive haemodynamic measures. Int J Cardiol. 2015 Feb 1;180:221-2
  6. Baruah R, Giannoni A, Willson K, Manisty CH, Mebrate Y, Kyriacou A, Yadav H, Unsworth B, Sutton R, Mayet J, Hughes AD, Francis DP. Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation. Open Heart. 2014 Aug 12;1(1):e000055
  7. Kyriacou A, Pabari PA, Mayet J, Lefroy D, Davies DW, Peters NS, Lim PB, Kanagaratnam P, Hughes AD, Francis DP, Whinnett ZI. Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally. Int J Cardiol. 2014 Feb 1;171(2):144-52.
  8. Whinnett ZI, Sohaib SM, Jones S, Kyriacou A, March K, Coady E, Mayet J, Hughes AD, Frenneaux M, Francis DP. British randomised controlled trial of AV and VV optimization (“BRAVO”) study: rationale, design, and endpoints. BMC Cardiovasc Disord. 2014 Apr 3;14(1):42
  9. Jamil-Copley S, Bokan R, Kojodjojo P, Qureshi N, Koa-Wing M, Hayat S, Kyriacou A, Sandler B, Sohaib A, Wright I, Davies DW, Whinnett Z, S Peters N, Kanagaratnam P, Lim PB. Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias. Heart Rhythm. 2014 Apr;11(4):587-94
  10. Jones S, Shun-Shin MJ, Cole GD, Sau A, March K, Williams S, Kyriacou A, Hughes AD, Mayet J, Frenneaux M, Manisty CH, Whinnett ZI, Francis DP. Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines. Europace. 2014 Apr;16(4):541-50
  11. Raphael CE, Kyriacou A, Jones S, Pabari P, Cole G, Baruah R, Hughes AD, Francis DP. Multinational evaluation of the interpretability of the iterative method of optimisation of AV delay for CRT. Int J Cardiol. 2013 Sep 20;168(1):407-13
  12. Kyriacou A, Li Kam Wa ME, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP. A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy. Int J Cardiol. 2013 Aug 10;167(3):954-64
  13. Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JE. Improvement in Coronary Blood Flow Velocity with Acute Biventricular Pacing is Predominantly Due to an Increase in a Diastolic Backward-Travelling Decompression (Suction) Wave. Circulation. 2012 Sep 11;126(11):1334-44
  14. Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegenmann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DP. Fully automatable, reproducible, noninvasive simple plethysmographic optimization: proof of concept and potential for implantability. Pacing Clin Electrophysiol. 2012 Aug;35(8):948-60
  15. Kyriacou A, Pabari PA, Francis DP. Cardiac resynchronization therapy is certainly cardiac therapy, but how much resynchronization and how much atrioventricular delay optimization? Heart Fail Rev. 2012 Nov;17(6):727-36
  16. Pabari PA, Willson K, Stegemann B, van Geldorp IE, Kyriacou A, Moraldo M, Mayet J, Hughes AD, Francis DP. When is an optimization not an optimization? Evaluation of clinical implications of information content (signal-to-noise ratio) in optimization of cardiac resynchronization therapy, and how to measure and maximize it. Heart Fail Rev. 2011 May;16(3):277-90
  17. Unsworth B, Casula RP, Kyriacou A, Yadav H, Chukwuemeka A, Cherian A, Stanbridge Rde L, Athanasiou T, Mayet J, Francis DP. The right ventricular annular velocity reduction caused by coronary artery bypass graft surgery occurs at the moment of pericardial incision. Am Heart J. 2010 Feb;159(2):314-22
  18. Yadav H, Unsworth B, Fontana M, Diller GP, Kyriacou A, Baruah R, Mayet J, Francis DP. Selective right ventricular impairment following coronary artery bypass graft surgery. Eur J Cardiothorac Surg. 2010 Feb;37(2):393-8
  19. Diller GP, Wasan BS, Kyriacou A, Patel N, Casula RP, Athanasiou T, Francis DP, Mayet J. Effect of coronary artery bypass surgery on myocardial function as assessed by tissue Doppler echocardiography. Eur J Cardiothorac Surg. 2008 Nov;34(5):995-9

Dr Nick Kelland

Specialties

General Cardiology
Electrophysiology
Pacing

Professional Profile

After graduating from Oxford, Dr Kelland completed General Medical Training in Newcastle, before gaining a British Heart Foundation funded PhD in Endothelial Function,  from the University of Edinburgh. He returned to the North East to train in Cardiology, sub-specialising in Electrophysiology and Devices whilst working at the Freeman, Newcastle and James Cook University (Middlesbrough) Hospitals. This was complemented by a Fellowship in the Royal Melbourne Hospital, Australia, working with Professor Jonathan Kalman. He took up his Consultant post in Cardiac Electrophysiology and Devices at the Northern General Hospital, Sheffield Teaching Hospitals Foundation NHS Trust  in 2012. He now performs over 250. Electrophysiological and Device procedures each year, dealing with all types of arrhythmia, included VT and AF, using the latest ablation techniques.

Current membership(s) of professional, national and regional bodies and university posts

  • Honorary Senior Lectureship, Sheffield University
  • Member Royal College of Physicians of Edinburgh
  • Member of British Heart Rhythm Society
  • Member of Hospital Consultants and Specialists Association

Publications

PhD Thesis

  1. Kelland NF. (2007) Investigation of the role of the endothelial cell Endothelin B receptor in cardiovascular function. University of Edinburgh.

Original Papers

  1. Bagnall AB and Kelland NF, Gulliver-Sloan FH, Davenport AP, Gray GA, Yanagisawa M, Webb DJ and Kotelevtsev YV. (2006). Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension: 48; 286-93.
  2. Kelland NF, Bagnall AJ, Morecroft I, Gulliver-Sloan FH, Dempsie Y, Nilsen M, Yanagisawa M, Maclean MR, Kotelevtsev YV, Webb DJ. Endothelial ET(B) Limits Vascular Remodelling and Development of Pulmonary Hypertension during Hypoxia. J Vasc Res. 2009; 47:16-22.
  3. Kelland NF, Kuc RE, Armour DL, Bagnall AJ, Gulliver-Sloan F, Maguire JJ, Davenport AP, Gray GA, Kotelevtsev Y and Webb DJ. Endothelial Cell Specific Knockout of the Endothelin B Receptor Demonstrates Its Crucial Role In The Clearance Of Endothelin-1. Can J Physiol Pharm 88: 644-
    651.
  4. Kumar S, Haqqani HM, Chan M, Lee J, Yudi M, Wong MC, Morton JB, Ling LH, Robinson T, Heck PM,Kelland NF, Halloran K, Spence SJ, Kistler PM, Kalman JM. (2013). Predictive value of impedance changes for real-time contact force measurements during catheter ablation of atrial arrhythmias in humans. Heart Rhythm: 10(7):962-9.
  5. Kumar S, Sutherland F, Lee JM, Robinson T, Heck PM, Wong MC, Kelland NF, Garg ML, Sparks PB. (2013) Effects of high dose intravenous fish oil on human atrial electrophysiology: implications for possible anti- and pro-arrhythmic mechanisms in atrial fibrillation. Int J Cardiol. 3;168(3):2754-
    60.
  6. Nelson T, Bhaktia A, Lee J, Sahu, J, Sheridan P, Bowes R and Kelland NF. Evaluation of a new same day discharge protocol for simple and complex pacing procedures. Europace (submitted).

Reviews/ Editorials/ Letters/ Case Reports

  1. Kelland NF, Webb, DJ. Book Review: ACE Inhibitors. British Journal of Clinical Pharmacology 2002;54:337-8.
  2. Kelland NF. Symposium Report: Expedition Medicine. J R Coll Physicians Edinburgh 2005. 35:353-5.
  3. Kelland NF, Webb, DJ. (2006). Clinical Trials of Endothelin Antagonists in Heart Failure: A Question of Dose? Experimental Biology and Medicine: 231; 696-699
  4. Battistini B, Berthiaume N, Kelland NF, Webb DJ and Kohan DE. (2006). Profile of Past and Current Clinical Trials Involving Endothelin Receptor Antagonists: The Novel “-Sentan” Class of Drug. Experimental Biology and Medicine: 231; 653-695.
  5. Kelland NF and Webb DJ. (2007). Clinical trials of endothelin antagonists in heart failure: publication is good for the public health. Heart: 93; 2-4.
  6. Kelland NF, Roberts AP. Letter by Kelland and Roberts regarding article, “Lipid management to reduce cardiovascular risk: a new strategy is required”. Circulation. 2008;118:e119.
  7. Leong KM, Kelland NF. (2013). Pre-excitation on the electrocardiogram: what next? Br J Hosp Med (Lond). 2013 Nov;74(11):636-40.
  8. Fent GJ, Kamaruddin H, Garg P, Iqbal A, Kelland NF and Hall IR. Hypertensive Emergency and Type 2 Myocardial Infarction Resulting From Pheochromocytoma and Concurrent Capnocytophaga Canimorsus Infection. Open Cardiovasc Med J. 2014 Jun 13;8:43-7
  9. Parker WAE, Sahu J, Lee JMS, Wheeldon NM, Al-Mohammed A, Cooke CJ, Wechalekar AD, Chantry A, Kelland NF. An Unusual Cause of Refractory Polymorphic Ventricular Tachycardia. European Heart J (submitted).Ananesthetists – d/w Park NottsPhysiologists – Ian and Greg and reps from industryCath lab nurses – JudithRadiographers – JamesManagers